Here, we used CIRIquant to analyse circRNA expression in RNA-seq datasets from H1N1 IAV-infected human tracheobronchial epithelial (HTBE) cells and validated selected circRNAs in A549-PB1 cells.
Both bulk and single-cell analyses revealed a correlation between the expression of “M” mRNA and the onset of the transcription-to-replication switch. Our findings demonstrate that mudRapp-seq offers
Influenza A viruses continuously circulate and change in several animal hosts, and the emergence of novel strains that are capable of causing human epidemics or pandemics is a serious possibility
Influenza virus basics Influenza A viruses are the only influenza viruses known to cause flu pandemics (i.e., global epidemics of flu disease). A pandemic can occur when a new and different influenza A
Influenza A viruses constantly circulate in many animal hosts, such as humans, birds, horses, dogs and pigs. Seasonal influenza virus infections in humans cause annual epidemics that result in millions of
The influenza virus adapts itself to infect human cells by point mutations or by reassortment with a gene segment from a different influenza virus [7, 8]. The first well documented influenza pandemic
Influenza A virus (IAV) represents a constant public health threat. The single-stranded, segmented RNA genome of IAV is replicated in host cell nuclei as a series of 8 ribonucleoprotein complexes (vRNPs)
Viruses have evolved to efficiently navigate host cells to deliver, express, and replicate their genetic material. Understanding the mechanisms underlying viral RNA localisation is paramount to designing
Abstract Influenza A viruses (IAVs) contain eight negative-sense single-stranded viral RNA (vRNA) molecules, which are transcribed into messenger RNA (mRNA) and replicated via complementary
Yang et al. investigate RNA secondary structures and RNA interaction networks of the IAV genome, enabling construction of structural models of the IAV genome, comparative analysis of viral RNA
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